First transform the gas into a liquid by subjecting it to pressure. You can use a bicycle pump for this. Then make a simple home centrifuge. Fill a standard-size bucket one-quarter full of liquid uranium hexafluoride. Attach a six-foot rope to the bucket handle. Now swing the rope (and attached bucket) around your head as fast as possible.
After your A-bomb is completed you'll have a pile of moderately fatal radioactive wastes like U-238. These are not dangerous, but you do have to get rid of them. You can flush leftovers down the toilet. (Don't worry about polluting the ocean, there is already so much radioactive waste there, a few more bucketfuls won't make any waves whatsoever.) If you're the fastidious type -- the kind who never leaves gum under their seat at the movies -- you can seal the nasty stuff in coffee cans and bury it in the backyard, just like Uncle Sam does. If the neighbor kids have a habit of trampling the lawn, tell them to play over by the waste. You'll soon find that they're spending most of their time in bed.